In the late 21st a disease called Hemophagia has genetically modified nearly an entire race of people, leaving them with such enhanced speed, intelligence, and strength that they resemble vampires in nearly every way. Fear begins to breed within the power elite as the disease continues to spread and those infected prove to be truly superhuman, and now, a civil war is brewing between uninfected humans and those altered by Hemophagia. Caught dead in the center of it is an infected woman called Violet (Milla Jovovich), who is bent on vengeance and has little left to lose. Provoked beyond reason by powers that will not rest until she and her people are dead, she will become everything her persecutors feared her to be.